Program 2020

The scientific program features experts from all regions of the world.  Please note that this schedule is subject to change. Changes, if necessary, will be updated on this page. Once sessions are finalized each will appear with a link to the session and related abstracts for viewing.  

[DAY 1] Sunday, August 2, 2020 


1.1.4 Microcrystal Electron Diffraction (MicroED) – Small Molecule & Macromolecules
Date: 8/2/20  12:00 PM EDT - 3:00 PM EDT
Sponsoring SIGs: Small Molecule/ Bio
Co-Sponsoring SIGs: CryoEM / YSIG
The field of microcrystal electron diffraction has rapidly progressed over the past 6 years. Recent advances have placed microED at the forefront of structure determination. Several experimental protocols exist that describe the process of sequential sampling of diffraction patterns from nanometer-sized crystals while a sample is tilted in a transmission electron microscope. This session will be focused on advances in software/hardware and discussion of the results from microED experiments.

 

 

 


1.2.5 From Materials to Crystallographic Analysis: An Neutrons/Materials/Powder Session 
Date: 8/2/20  12:00 PM EDT- 3:00 PM EDT
Sponsoring SIGs: Neutron, Materials, Powder Diffraction
 
The Neutrons, Materials and Powder Diffraction SIGs are presenting a session that provides an opportunity to learn about materials ranging from correlated quantum materials to network structures, and new approaches to analyze crystallographic data. 
 

Date: 8/2/20  12:00 PM EDT- 3:00 PM EDT

 

This session will be comprised of talks describing exciting new results in structural biology. The majority of talks will be selected from submitted abstracts.

 

 


1.2.4 Advances in Fiber Diffraction and General Methods
Date: 8/2/20  12:00 PM EDT - 3:00 PM EDT
Sponsoring SIGs: Fiber
Chair(s): Joseph OrgelTom Irving

Date: 8/2/20  4:00 PM EDT - 5:00 PM EDT

[DAY 2] Monday, August 3, 2020 


PL1 Etter Award: Nozomi Ando
Date: 8/3/20 11:00 AM EDT - 12:00 PM EDT

 

 

 

 

 


2.1.4 Frontiers in SAS
Date: 8/3/20  12:00 PM EDT - 3:00 PM EDT
Sponsoring SIGs: SAS
Co-Sponsoring SIGs: Light Sources
Chair(s): Tom GrantJesse Hopkins

 

Recent advances in light sources, experimental methods and computational algorithms have enabled exciting new discoveries using small angle scattering (SAS). This session is devoted to discussing the latest advances in methods and applications of X-ray and neutron SAS. The primary aim is to bring together cutting-edge advances utilizing SAS on both soft matter and biological systems, including time-resolved studies, contrast matching, dynamic and flexible systems, hybrid modeling, novel experimental apparatus and methods, and new computational approaches. This session will reflect the state of the art in SAS methods.

 

 


2.2.3 General Interest I
Date: 8/3/20 12:00 PM EDT - 3:00 PM EDT 
Sponsoring SIGs: General Interest
Co-Sponsoring SIGs: YSIG
 

General Interest sessions are the forum for topics of broad interest to the crystallographic community or for presentations that do not fit the specific theme of other sessions. All presentations are selected from submitted abstracts.

 


1.2.1 Remote Access Facilities:  What, Where & How?
Date: 8/3/20 12:00 PM EDT - 3:00 PM EDT
Sponsoring SIGs: Light Sources/YSIG

 


2.1.2 Advances in Software Methods and Tools for Cryo-EM
Date: 8/3/20  12:00 PM EDT - 3:00 PM EDT
Sponsoring SIGs: CryoEM 

 


Date: 8/3/20  4:00 PM EDT - 5:00 PM EDT
 

Date: 8/4/20 12:00 PM EDT - 3:00 PM EDT
Sponsoring SIGs: BioMac
Co-Sponsoring SIGs: YSIG, Canadian

 

The Hot Structures session will feature talks selected from submitted abstracts describing the newest results from structural studies of biologically important macromolecules. Submissions are welcome that describe high-impact structures which provide insights into structure-function relationships, new biological insights and mechanisms, and methods development. Studies may include the use of X-ray crystallography, XFEL, hybrid methods, and cryo-electron microscopy.
 
Confirmed Speakers:
  • Frank van Delft, Oxford University, has produced extensive structures of the main protease, a major drug target, and complexes with inhibitors found through high-throughput screening.
  • Andrzej Joachimiak, Argonne National Laboratory, and his group have submitted structures of many SARS-CoV2 proteins, including the papain-like protease and RNA processing enzymes.
  • Stephen Burley, Rutgers and RCSB PDB, has curated and overseen distribution of all the available structures.
  • Ian Wilson, Scripps, has studied specificities of important vaccine targets including antibody complexes.
  • Jason McLellan, UT Austin: Development of Vaccines and Antibodies for SARS-CoV-2 Cryo-EM studies of the Spike protein.
  • Joanne Lemieux, University of Alberta: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication.

 


[DAY 4] Wednesday, August 5, 2020


PL2 Ronglie Award: James Holton
Date: 8/5/20 11:00 AM EDT - 12:00 PM EDT

 

 

 

 

 


Date: 8/5/20 12:00 PM EDT - 3:00 PM EDT
 

 

 

 

 


4.1.2 Structural Dynamics I. Protein Collective Motions Studied by X-ray Scattering and Diffraction
Date: 8/5/20 12:00 PM EDT - 3:00 PM EDT
Sponsoring SIGs: SAS
Co-Sponsoring SIGs: BioMac
 
The macromolecules of life are often likened to elaborate machines, with many moving parts that must work collectively to achieve biological function. However, it has proven exceedingly difficult to understand how these machines work from traditional, static “snapshots” of structure alone. Thus, a new field of dynamic structural biology has emerged at the intersection of a diverse and evolving set of techniques. In Part I of this two-part session sponsored by Structural Dynamics, we focus on collective motions illuminated by X-ray scattering and diffraction. How are signals transduced within a protein? How are enzymatic activities coordinated in multi-step reactions? Are collective vibrational modes important for activity? This session highlights how cutting-edge X-ray methods, especially time-resolved SAXS/WAXS and crystallography, are providing insights into the dynamic nature of proteins.
 

4.2.4 Physics and Chemistry of Matter Under Extreme Conditions
Date: 8/5/20 12:00 PM EDT - 3:00 PM EDT
Sponsoring SIGs: Materials/Neutrons/Powder
Chair(s): Yue Meng / Bianca Haberl
 
The application of extreme conditions such as pressure, temperature and field results in dramatic changes in all forms of matter. Under these conditions, matter undergoes phase transitions, displays rich new physical and chemical phenomena and can even yield new structures and materials not accessible in any other way. The aim of this session is thus to bring together the most recent advances and discoveries in both experimental and theoretical research that highlight these unique behaviors. Therefore, the session will address the many behaviors that are observed under extreme conditions. It will cover structural, electronic and magnetic properties, phonon and lattice dynamics, new materials synthesis, plastic deformation and melting. In addition, this session will also provide a forum for highlighting the state-of-the-art synchrotron and neutron techniques that enable new experimental research opportunities. Finally, it will also provide a platform for developmental ideas to expand the scope of future materials research under extreme conditions. 

3.1.1 CryoEM in Pharma: Structure-based drug design beyond X-ray crystallography
Date: 8/5/20 12:00 PM EDT - 3:00 PM EDT 
Sponsoring SIGs: Industrial
Co-Sponsoring SIGs: CryoEM
Chair(s): Seungil HanAlok Sharma

 

For long, X-ray crystallography had been the backbone of structure based drug design. However, since the advent of direct electron detectors in 2012 and development in data processing algorithms in the field, single particle cryo-EM has become a widely and routinely used structure solution method for difficult targets including integral membrane proteins. Pharmaceutical companies kept them in par with the development of the technique and readily expanded their drug design portfolios to non-crystallizable proteins. In this session, we are going to learn about efforts and success with cryo-EM which pharmaceutical companies have made in the past few years. The session will also talk about challenges and path forward with this technique.
 

Date: 8/5/20  4:00 PM EDT - 5:00 PM EDT 
 

[Day 5] Thursday, August 6, 2020


Date: 8/6/20 11:00 AM EDT - 12:00 PM EDT 

 

 

 

 

 


Date: 8/6/20 12:00 PM EDT - 3:00 PM EDT 
 

 

 

 

 


4.2.2 Structural Dynamics II. Conformational Ensembles of Proteins Studied by Cryo-EM and X-ray Scattering
Date: 8/6/20 12:00 PM EDT - 3:00 PM EDT 
Sponsoring SIGs: CryoEM
Co-Sponsoring SIGs: SAS

 

The macromolecules of life are often likened to elaborate machines, with many moving parts that must work collectively to achieve biological function. However, it has proven exceedingly difficult to understand how these machines work from traditional, static “snapshots” of structure alone. Thus, a new field of dynamic structural biology has emerged at the intersection of a diverse and evolving set of techniques. In Part II of this two-part session sponsored by Structural Dynamics, we focus on the analysis of conformational and thermodynamic ensembles by cutting-edge approaches in cryo-electron microscopy (cryo-EM) and solution X-ray scattering. Recent developments in cryo-EM bring us closer to ensemble-like structural depictions that attempt to describe and better understand both compositional and conformational particle heterogeneity. Meanwhile, X-ray scattering allows for an unmatched view of a protein’s dynamic behavior in solution, and new avenues of analysis reveal meaningful structural information. This session highlights how cryo-EM and SAXS are uncovering the roles that conformational changes, intrinsic disorder, and structural variation play in protein function.

 


4.2.3 General Interest II
Date: 8/6/20 12:00 PM EDT - 3:00 PM EDT 
Sponsoring SIGs: General Interest
Co-Sponsoring SIGs: YSIG

 

General Interest sessions are the forum for topics of broad interest to the crystallographic community or for presentations that do not fit the specific theme of other sessions. All presentations are selected from submitted abstracts.

 

 
Date: 8/6/20  4:00 PM EDT - 5:00 PM EDT 
 

 


[DAY 6] Friday, August 7, 2020

PL4 Wood Award: Alan Alda Center
Date: 8/7/20 11:00 AM EDT - 12:00 PM EDT 
 
1.2.3 Communicating Science to the Public
Date: 8/2/20 12:00 PM EDT- 3:00 PM EDT
Sponsoring SIGs: Communications
Co-Sponsoring SIGs: Canadian
Chair(s): Brian Patrick / Rajni Miglani Bhardwaj 

 

Whether it be discussing climate change, public health policies, or simply conveying the impact of their research to the public, scientists need effective strategies to communicate and engage a broad audience. This session aims to bring together speakers discussing their experiences and approaches to scientific communication.


3.1.4 Cool Structures: Important Science from Small Molecules
Date: 8/7/20 12:00 PM EDT - 3:00 PM EDT 
Sponsoring SIGs: Small Molecule
Co-Sponsoring SIGs: YSIG, Canadian

 

This session aims to both highlight interesting structures of small molecules (<100 atoms per molecule) and bring to the foreground the science enabled by small-molecule structure analysis. Speakers will be selected from contributed abstracts. Submissions from students are encouraged.
 

4.1.1 Methods and Tools for Crystallography and Cryo-EM Sample Preparation
Sponsoring SIGs: Industrial, BioMac, CryoEM

 

With the technological advancements in both X-ray crystallography and Cryo-EM, structural biology techniques are becoming readily accessible to all labs. Although we are witnessing many significant strides in this field, the main bottleneck for both methods is still the preparation of high-quality protein samples. In this session we will highlight the latest methods and techniques for protein sample preparation for both crystallography and Cryo-EM experiments.

 

Date: 8/7/20 12:00 PM EDT  - 3:00 PM EDT 
Chair(s): George Lountos / Nicole Fraser 
 
This session will be comprised of talks describing exciting new results in structural biology. The majority of talks will be selected from submitted abstracts.